Background: Emergency exception to informed consent regulation was introduced to provide a venue to perform research on subjects in emergency situations before obtaining informed consent. For a study to proceed, institutional review boards need to determine if the regulations have been met.Aim: To determine IRB members’ experience reviewing research protocols using emergency exception to informed consent.Methods: This qualitative research used semistructured telephone interviews of 10 selected IRB members from around the US in the fall of 2003. IRB members were chosen (...) as little is known about their views of exception to consent, and part of their mandate is the protection of human subjects in research. Interview questions focused on the length of review process, ethical and legal considerations, training provided to IRB members on the regulations, and experience using community consultation and notification. Content analysis was performed on the transcripts of interviews. To ensure validity, data analysis was performed by individuals with varying backgrounds: three emergency physicians, an IRB member and a layperson.Results: Respondents noted that: emergency exception to informed consent studies require lengthy review; community consultation and notification regulations are vague and hard to implement; current regulations, if applied correctly, protect human subjects; legal counsel is an important aspect of reviewing exception to informed-consent protocols; and IRB members have had little or no formal training in these regulations, but are able to access materials needed to review such protocols.Conclusions: This preliminary study suggests that IRB members find emergency exception to informed consent studies take longer to review than other protocols, and that community consultation and community notification are the most difficult aspect of the regulations with which to comply but that they adequately protect human subjects. (shrink)

Some people have supposed that utility is good in itself, non-in-strumentally good, as distinct from good because conducive to other good things. And in modern versions of this view, utility often means want-satisfaction, as distinct from pleasure or happiness. For your want that p to be satisfied, is it necessary that you know or believe that p, or sufficient merely that p is true? However that question is answered, there are problems with the view that want-satisfaction is a non-instrumental good. (...) What if you want something only because you have a false belief? What if the time at which you want that p is fifty or five hundred years before the time to which p itself refers? To meet these difficulties, qualifications have to be introduced, and much has been written about how exactly these qualifications are to be framed.1 There is however what may be a rather more serious objection to the view that want-satisfaction is a non-instrumental good, or rather to the combination of that view with the principle that it is sufficient for your want that p to be satisfied simply that p is true. The objection is that this combination forces you to give undue weight to the mere acquisition of desires when you come to make judgements about changes in the value of things. It forces you to say that for any true proposition p, which initially you do not want to be true, your mere acquisition of a desire that p will, other things being equal, make the world better. Non-instrumental value can be increased merely by multiplying desires, even though everything else remains the same. Surely, however, improving the world is not as easy as that. (shrink)

When do two mental items belong to the same life? We could be content with the answer -just when they have certain volitional qualities in common. An affinity is noted between that theory and Berkeley's early doctrine of the self. Some rivals of the volitional theory invoke a spiritual or physical owner of mental items. They run a risk either of empty formality or of causal superstition. Other rivals postulate a non-transitive and symmetrical relation in the set of mental items. (...) They must allow in consequence either for joint ownership of one and the same mental item, or for incompatible simultaneous decisions by one and the same person, or for new forms of death. This makes them disquieting. Another rival invokes a transitive and symmetrical relation defined in terms of co-consciousness. Even that allows for incongruous simultaneities. The volitional theory is free from such disadvantages. (shrink)

N. M. L. Nathan; VIII*—Democracy, Proceedings of the Aristotelian Society, Volume 93, Issue 1, 1 June 1993, Pages 123–138, https://doi.org/10.1093/aristotelian/.

The purpose of this essay is to show that there was one person, perhaps only one, who developed a rigorously scientific cosmology nearly two thousand years ago. Cosmology is the largest of all subjects, with a long history, and the cosmology considered here is the one that endured for the longest part, nearly three-quarters, of that history. By cosmology I mean a description of the universe as a whole and of the arrangement of its principal parts. But by scientific cosmology, (...) I mean something more. For a cosmology to be considered scientific, three criteria must be met: it must be quantitative, physical, and empirical. Quantitative means that it must assign some scale of distances and sizes to its parts. Physical means that it must rest upon some kind of physical or mechanical principles, causes, for the ordering and motion of its parts. Finally, empirical means that it must either be derived from observation or, if derived theoretically, as from physical or mechanical principles, it must be confirmed by observation. I set out these criteria, which may not be exclusive or exhaustive but are surely within reason, in order to define our subject and exclude mythological or theological cosmologies, which generally meet none of the criteria, and philosophical cosmologies, as those of Plato, Aristotle, and Descartes, which may meet one or two in some way, although not rigorously, but surely do not meet all three. I am not concerned with whether the cosmology or the criteria upon which it is based are correct. Compared to our present understanding, the scale may be off by orders of magnitude, the physics may be entirely mistaken, and the observations may be inaccurate. But if all three are present I would call the cosmology scientific, and if not I would not call the cosmology scientific. (shrink)

Context: Immunity includes cognitive concepts: the organism is thought to specifically recognize foreign materials and develop a memory of these encounters. Vaccines are thought to work by enhancing this immunological memory. Lymphocytes are key cells and specific antibodies are key molecules in immune recognition. Antibodies are blood proteins called “immunoglobulins.” Spontaneously formed immunoglobulins are seen as “natural” antibodies to dietary components and commensal bacteria. Immune cognition is used simply as a didactic metaphor. Problem: Do the cognitive aspects of immunology stem (...) from the activities of cells and molecules, or are they ascribed by the immunologist operating as a human observer? (1) An immense variety of immunoglobulins may bind to the same antigen with different binding energies. It is the immunologist who arbitrates the boundary between those that are specific (and declared antibodies) and those that are not. Specific antibodies serve as functional labels pasted onto natural immunoglobulins, as if they were recognizing elements. Is this “arbitration” the true cognitive event ascribed to immunoglobulins and lymphocytes? (2) A major impasse exists between progress in experimental immunology and its translation into clinical results. A proper understanding of immunological activity demands a wider view of an organism’s biology and, also, of the interference of human observers in delineating experimental realities, such as the specificity of immune recognition. Maturana’s biology of cognition and language provides one such approach. Method: Use of Maturana’s biology of cognition and language concepts to describe immunological activity. Results: A whole new understanding of immunological activity is suggested. Implications: A major change in the way of seeing is proposed that may eventually help the translation of this knowledge into clinical results. Furthermore, the immune system may also become a proper model for cognitive analyses. (shrink)

Beneath metaphysical problems there often lies a conflict between what we want to be true and what we believe to be true. Nathan provides a general account of the resolution of this conflict as a philosophical objective, showing that there are ways of thinking it through systematically with a view to resolving or alleviating it. The author also studies in detail a set of interrelated conflicts about the freedom and the reality of the will. He shows how difficult it is (...) to find a freedom either of decision or of action which is both an object of reflective desire and an object of rational belief. He also examines conflicts about volition as such, contending that the veridicality of volitional experience is no less easy to doubt than the veridicality of our experience of colors. In this context, arguments emerge for a voluntarist theory of the self. Nathan's important book will be essential reading for all philosophers interested in free will, volition, the self, and the methodology of metaphysics. (shrink)

This paper describes the topological aspect of a logic-based, artificial intelligence approach to formalising the qualitative description of spatial properties and relations, and reasoning about those properties and relations. This approach, known as RCC theory, has been under development for several years at the University of Leeds. The main rationale for this project is that qualitative descriptions of spatial properties and relationships, and qualitative spatial reasoning, are of fundamental importance in human thinking about the world: even where quantitative spatial data (...) are most important, they must be attached to the components of a perceived spatial structure if we are to make use of them. RCC theory covers other qualitative aspects of spatial description and reasoning, but the topological properties and relations of spatially extended entities are fundamental to our work. The topological formalisms used by mathematicians are, in general, not well suited to the task of formalising the kinds of ‘common-sense’ or ‘everyday’ qualitative spatial description and reasoning which are our primary interest. Nevertheless, we must come to grips with the concepts of topology as practised by mathematicians if we are not to risk constantly ‘reinventing wheels’. (shrink)

Any study of the religious situation in Ukraine always faces one problem - the lack of detailed information on the number of believers of a particular denomination. The most recent census did not include the question of denominational affiliation, as it was considered a violation of the principle of freedom of conscience. The only officially recognized statistical unit we have is the religious community. Approximate number of adherents of a particular denomination is given by the results of sociological research. However, (...) it is precisely at the border of statistics and sociology that one of the paradoxes that the current religious situation in Ukraine is rich in is the paradox of the inconsistency of sociological data with statistics. Thus, according to the State Committee for National Religions of Ukraine as of January 1, 2009, there were 11539 communities of the Ukrainian Orthodox Church of the Moscow Patriarchate, 4128 communities of the Ukrainian Orthodox Church of the Kiev Patriarchate, and 1184 communities of the Ukrainian Autocephalous Orthodox Church. As the traditional Greek churches include the Ukrainian Greek Catholic Church and Roman Catholics, their number is 3570 and 907 communities, respectively. (shrink)

The article Deflating the "DBS causes personality changes" bubble, written by Frederic Gilbert, J. N. M. Viaña and C. Ineichen, was originally published electronically on the publisher’s internet portal on 19 June 2018 without open access.

In "Warrant and Proper Function" Plantinga argues that atheistic Naturalism is self-defeating. What is the probability that our cognitive faculties are reliable, given this Naturalism and an evolutionary explanation of their origins? Plantinga argues that if the Naturalist is modest enough to believe that it is irrational to have any belief as to the value of this probability, then he is irrational even to believe his own Naturalism. I suggest that Plantinga's argument has a false premise, and that even if (...) his argument were sound there would be reasons for doubting whether the Naturalist should respond to it by abandoning his Naturalism. (shrink)

The idea that deep brain stimulation (DBS) induces changes to personality, identity, agency, authenticity, autonomy and self (PIAAAS) is so deeply entrenched within neuroethics discourses that it has become an unchallenged narrative. In this article, we critically assess evidence about putative effects of DBS on PIAAAS. We conducted a literature review of more than 1535 articles to investigate the prevalence of scientific evidence regarding these potential DBS-induced changes. While we observed an increase in the number of publications in theoretical neuroethics (...) that mention putative DBS-induced changes to patients’ postoperative PIAAAS, we found a critical lack of primary empirical studies corroborating these claims. Our findings strongly suggest that the theoretical neuroethics debate on putative effects of DBS relies on very limited empirical evidence and is, instead, reliant on unsubstantiated speculative assumptions probablyin lieuof robust evidence. As such, this may reflect the likelihood of a speculative neuroethics bubble that may need to be deflated. Nevertheless, despite the low number of first-hand primary studies and large number of marginal and single case reports, potential postoperative DBS changes experienced by patients remain a critical ethical concern. We recommend further empirical research in order to enhance theoretical neuroethics work in the area. In particular, we call for the development of better instruments capable of capturing potential postoperative variations of PIAAAS. (shrink)

vyp. 1. [Without special title] -- vyp. 2. Ėpokhi svobodnoĭ konkurent︠s︡ii i burzhuaznykh revoli︠u︡t︠s︡iĭ -- vyp. 3 Ėpokha monopolisticheskogo kapitala, imperializma, sot︠s︡ialisticheskikh revoli︠u︡t︠s︡iĭ, protivostoi︠a︡nii︠a︡ dvukh sistem, osvobozhdeniia︡︠ koloniĭ, krizisa "realʹnogo sot︠s︡ializma" i formirovanii︠a︡ za Zapade "sot︠s︡ialʹnogo gosudarstva".

I argue for two principles by combining which we can construct a sound cosmological argument. The first is that for any true proposition p's if 'there is an explanation for p's truth' is consistent then there is an explanation for p's truth. The second is a modified version of the principle that for any class, if there is an explanation for the non-emptiness ofthat class, then there is at least one non-member ofthat class which causes it not to be empty.

В книге рассматривается феномен параллельного развития, взаимодействия, взаимовлияния и сближения языка русской философии и поэзии 10-21 вв. Книга предназначена для филологов и философов и преподавателей русского языка.